Počet záznamů: 1

The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors

  1. 1.
    0366424 - BFU-R 2012 RIV GB eng J - Článek v odborném periodiku
    Procházková, Jiřina - Kabátková, Markéta - Bryja, Vítězslav - Umannová, Lenka - Bernatík, O. - Kozubík, Alois - Machala, M. - Vondráček, Jan
    The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors.
    Toxicological Sciences. Roč. 122, č. 2 (2011), s. 349-360 ISSN 1096-6080
    Grant CEP: GA ČR(CZ) GD204/09/H058
    Grant ostatní: GA ČR(CZ) GA524/09/1337
    Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Klíčová slova: dioxin * beta-catenin * AhR
    Kód oboru RIV: BO - Biofyzika
    Impakt faktor: 4.652, rok: 2011

    Beta-catenin is a key integrator of cadherin-mediated cell-cell adhesion and transcriptional regulation through the Wnt/beta-catenin pathway, which plays an important role in liver biology. In the present study, we showed that, although beta-catenin may augment the expression of selected target genes of the AhR, a transcriptional factor mediating toxic effects of persistent organic pollutants, the AhR activation may lead to downregulation of Wnt/beta-catenin signaling, and alterations in differentiation and/or proliferative status of liver progenitor cells.
    Trvalý link: http://hdl.handle.net/11104/0201426