The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors

0366424 - BFÚ 2012 RIV GB eng J - Článek v odborném periodiku
Procházková, Jiřina - Kabátková, Markéta - Bryja, Vítězslav - Umannová, Lenka - Bernatík, O. - Kozubík, Alois - Machala, M. - Vondráček, Jan
The interplay of the aryl hydrocarbon receptor and beta-catenin alters both AhR-dependent transcription and Wnt/beta-catenin signaling in liver progenitors.
Toxicological Sciences. Roč. 122, č. 2 (2011), s. 349-360. ISSN 1096-6080. E-ISSN 1096-0929
Grant CEP: GA ČR(CZ) GD204/09/H058
Grant ostatní: GA ČR(CZ) GA524/09/1337
Program: GA
Výzkumný záměr: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Klíčová slova: dioxin * beta-catenin * AhR
Kód oboru RIV: BO - Biofyzika
Impakt faktor: 4.652, rok: 2011

Beta-catenin is a key integrator of cadherin-mediated cell-cell adhesion and transcriptional regulation through the Wnt/beta-catenin pathway, which plays an important role in liver biology. In the present study, we showed that, although beta-catenin may augment the expression of selected target genes of the AhR, a transcriptional factor mediating toxic effects of persistent organic pollutants, the AhR activation may lead to downregulation of Wnt/beta-catenin signaling, and alterations in differentiation and/or proliferative status of liver progenitor cells.
Trvalý link: http://hdl.handle.net/11104/0201426