Počet záznamů: 1

Gliadin fragments promote migration of dendritic cells

  1. 1.
    0361617 - MBU-M 2012 RIV US eng J - Článek v odborném periodiku
    Chládková, Barbara - Kamanová, Jana - Palová-Jelínková, Lenka - Cinová, Jana - Šebo, Peter - Tučková, Ludmila
    Gliadin fragments promote migration of dendritic cells.
    Journal of Cellular and Molecular Medicine. Roč. 15, č. 4 (2011), 938-948 ISSN 1582-1838
    Grant CEP: GA ČR GA310/07/0414; GA ČR GD310/08/H077; GA ČR GA310/08/0447; GA AV ČR IAA500200801; GA AV ČR IAA500200914
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: celiac disease * gliadin * dendritic cell
    Kód oboru RIV: EC - Imunologie
    Impakt faktor: 4.125, rok: 2011

    This study provides a new insight into pathogenic features of gliadin fragments by demonstrating their ability to promote DC migration, which is a prerequisite for efficient priming of naive T cells, contributing to celiac disease pathology. In genetically predisposed individuals, ingestion of wheat gliadin provokes a T-cell-mediated enteropathy, celiac disease. Gliadin fragments were previously reported to induce phenotypic maturation and Th1 cytokine production by human dendritic cells (DCs) and to boost their capacity to stimulate allogeneic T cells. Here, we monitor the effects of gliadin on migratory capacities of DCs. Using transwell assays, we show that gliadin peptic digest stimulates migration of human DCs and their chemotactic responsiveness to the lymph node-homing chemokines CCL19 and CCL21
    Trvalý link: http://hdl.handle.net/11104/0198894