Gliadin fragments promote migration of dendritic cells

0361617 - MBÚ 2012 RIV US eng J - Článek v odborném periodiku
Chládková, Barbara - Kamanová, Jana - Palová-Jelínková, Lenka - Cinová, Jana - Šebo, Peter - Tučková, Ludmila
Gliadin fragments promote migration of dendritic cells.
Journal of Cellular and Molecular Medicine. Roč. 15, č. 4 (2011), 938-948. ISSN 1582-1838. E-ISSN 1582-4934
Grant CEP: GA ČR GA310/07/0414; GA ČR GD310/08/H077; GA ČR GA310/08/0447; GA AV ČR IAA500200801; GA AV ČR IAA500200914
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: celiac disease * gliadin * dendritic cell
Kód oboru RIV: EC - Imunologie
Impakt faktor: 4.125, rok: 2011

This study provides a new insight into pathogenic features of gliadin fragments by demonstrating their ability to promote DC migration, which is a prerequisite for efficient priming of naive T cells, contributing to celiac disease pathology. In genetically predisposed individuals, ingestion of wheat gliadin provokes a T-cell-mediated enteropathy, celiac disease. Gliadin fragments were previously reported to induce phenotypic maturation and Th1 cytokine production by human dendritic cells (DCs) and to boost their capacity to stimulate allogeneic T cells. Here, we monitor the effects of gliadin on migratory capacities of DCs. Using transwell assays, we show that gliadin peptic digest stimulates migration of human DCs and their chemotactic responsiveness to the lymph node-homing chemokines CCL19 and CCL21
Trvalý link: http://hdl.handle.net/11104/0198894