Počet záznamů: 1

Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome

  1. 1.
    0358902 - FGU-C 2012 RIV US eng J - Článek v odborném periodiku
    Pravenec, Michal - Kajiya, T. - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šimáková, Miroslava - Šilhavý, Jan - Malínská, H. - Oliyarnyk, O. - Kazdová, L. - Fan, J. - Wang, J. - Kurtz, T. W.
    Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome.
    Hypertension. Roč. 57, č. 4 (2011), s. 731-737 ISSN 0194-911X
    Grant CEP: GA MZd(CZ) NS9759; GA MŠk(CZ) ME08006; GA MŠk(CZ) 1M0520; GA ČR(CZ) GAP301/10/0290; GA ČR GAP303/10/0505; GA AV ČR(CZ) IAA500110805
    Grant ostatní:EC(XE) HEALTH-F4-2010-241504
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: C-reactive protein * metabolic syndrome * transgenic rat
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 6.207, rok: 2011

    We sought to investigate whether increased levels of human CRP, per se, can promote increases in blood pressure and disturbances in glucose and lipid metabolism characteristic of the metabolic syndrome. To accomplish this goal, we transgenically expressed human CRP in the spontaneously hypertensive rat (SHR) and found that that increased CRP is more than just a marker of inflammation and can directly promote multiple features of the metabolic syndrome
    Trvalý link: http://hdl.handle.net/11104/0196813