Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome

0358902 - FGÚ 2012 RIV US eng J - Článek v odborném periodiku
Pravenec, Michal - Kajiya, T. - Zídek, Václav - Landa, Vladimír - Mlejnek, Petr - Šimáková, Miroslava - Šilhavý, Jan - Malínská, H. - Oliyarnyk, O. - Kazdová, L. - Fan, J. - Wang, J. - Kurtz, T. W.
Effects of Human C-Reactive Protein on Pathogenesis of Features of the Metabolic Syndrome.
Hypertension. Roč. 57, č. 4 (2011), s. 731-737. ISSN 0194-911X. E-ISSN 1524-4563
Grant CEP: GA MZd(CZ) NS9759; GA MŠMT(CZ) ME08006; GA MŠMT(CZ) 1M0520; GA ČR(CZ) GAP301/10/0290; GA ČR GAP303/10/0505; GA AV ČR(CZ) IAA500110805
Grant ostatní: EC(XE) HEALTH-F4-2010-241504
Výzkumný záměr: CEZ:AV0Z50110509
Klíčová slova: C-reactive protein * metabolic syndrome * transgenic rat
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 6.207, rok: 2011

We sought to investigate whether increased levels of human CRP, per se, can promote increases in blood pressure and disturbances in glucose and lipid metabolism characteristic of the metabolic syndrome. To accomplish this goal, we transgenically expressed human CRP in the spontaneously hypertensive rat (SHR) and found that that increased CRP is more than just a marker of inflammation and can directly promote multiple features of the metabolic syndrome
Trvalý link: http://hdl.handle.net/11104/0196813