Počet záznamů: 1

To suppress to rescue? Changing the approach for recalling anticancer immune responses

  1. 1.
    0354370 - MBU-M 2011 RIV US eng J - Článek v odborném periodiku
    Vannucci, Luca
    To suppress to rescue? Changing the approach for recalling anticancer immune responses.
    Front Biosci (Schol Ed). -, č. 2 (2010), s. 1189-1197 ISSN 1945-0516
    Grant CEP: GA AV ČR IAA500200917
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: inflammmation * cancer * immunity
    Kód oboru RIV: EC - Imunologie

    The tumor microenvironment plays a fundamental role in influencing the anticancer immune response. Recent experimental anticancer therapy show that some anticancer chemotherapeutics can improve tumor control by acting on immunity and can also be used in immunosuppressive treatments. On the base of current inflammatory cancer microenvironment model, we suggest recovering the anticancer response by paradoxically inducing a temporary immune suppression. In this paper, we review present concepts about inflammation and immunity in the cancer microenvironment, as well as experimental data from recent literature supporting this paradoxical intervention hypothesis
    Trvalý link: http://hdl.handle.net/11104/0193384