To suppress to rescue? Changing the approach for recalling anticancer immune responses

0354370 - MBÚ 2011 RIV US eng J - Článek v odborném periodiku
Vannucci, Luca
To suppress to rescue? Changing the approach for recalling anticancer immune responses.
Front Biosci (Schol Ed). -, č. 2 (2010), s. 1189-1197. ISSN 1945-0516
Grant CEP: GA AV ČR IAA500200917
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: inflammmation * cancer * immunity
Kód oboru RIV: EC - Imunologie

The tumor microenvironment plays a fundamental role in influencing the anticancer immune response. Recent experimental anticancer therapy show that some anticancer chemotherapeutics can improve tumor control by acting on immunity and can also be used in immunosuppressive treatments. On the base of current inflammatory cancer microenvironment model, we suggest recovering the anticancer response by paradoxically inducing a temporary immune suppression. In this paper, we review present concepts about inflammation and immunity in the cancer microenvironment, as well as experimental data from recent literature supporting this paradoxical intervention hypothesis
Trvalý link: http://hdl.handle.net/11104/0193384