Počet záznamů: 1

Integrated liquid chromatography–heated nebulizer microchip for mass spectrometry

  1. 1.
    0354131 - MBU-M 2011 RIV NL eng J - Článek v odborném periodiku
    Haapala, M. - Saarela, V. - Pól, Jaroslav - Kolari, K. - Kotiaho, T. - Franssila, S. - Kostiainen, R.
    Integrated liquid chromatography–heated nebulizer microchip for mass spectrometry.
    Analytica Chimica Acta. Roč. 662, č. 2 (2010), s. 163-169 ISSN 0003-2670
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Liquid chromatography * Mass spectrometry * Microchip
    Kód oboru RIV: CB - Analytická chemie, separace
    Impakt faktor: 4.310, rok: 2010

    A new integrated microchip for liquid chromatography–mass spectrometry (LC–MS) is presented. The chip is made from bonded silicon and glass wafers with structures for a packed LC column channel, a micropillar frit, a channel for optional optical detection, and a heated vaporizer section etched in silicon and platinum heater elements on the glass cover. LC eluent is vaporized and mixed with nebulizer gas in the vaporizer section and the vapor is sprayed out from the chip. Nonpolar and polar analytes can be efficiently ionized in the gas phase by atmospheric pressure photoionization (APPI) as demonstrated with polycyclic aromatic hydrocarbons (PAHs) and selective androgen receptor modulators (SARMs). This is not achievable with present LC–MS chips, since they are based on electrospray ionization, which is not able to ionize nonpolar compounds efficiently
    Trvalý link: http://hdl.handle.net/11104/0193201