Počet záznamů: 1

Carboxylated calixarenes bind strongly to CD69 and protect CD69+ killer cells from suicidal cell death induced by tumor cell surface ligands

  1. 1.
    0350689 - MBU-M 2011 RIV GB eng J - Článek v odborném periodiku
    Bezouška, K. - Šnajdrová, R. - Křenek, K. - Vančurová, Markéta - Kádek, A. - Adámek, D. - Lhoták, P. - Kavan, Daniel - Hofbauerová, Kateřina - Man, Petr - Bojarová, Pavla - Křen, Vladimír
    Carboxylated calixarenes bind strongly to CD69 and protect CD69+ killer cells from suicidal cell death induced by tumor cell surface ligands.
    Bioorganic & Medicinal Chemistry. Roč. 18, č. 4 (2010), s. 1434-1440 ISSN 0968-0896
    Grant CEP: GA MŠk OC 136; GA MŠk 1M0505; GA ČR GA303/09/0477; GA ČR GD305/09/H008; GA AV ČR IAA400200503; GA AV ČR KJB500200612
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: Carboxylated calixarenes * Lymphocyte activation * Receptor cross-linking
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 2.978, rok: 2010

    We have recently identified a new class of high affinity ligands for CD69 leukocyte membrane receptor, carboxylated calixarenes. Of the three compounds investigated here, thiacalix[4]arene had the highest affinity for CD69 in direct binding assays, and proved to be the most specific inhibitor of CD69 identified so far in receptor precipitation and cellular activation experiments. Carboxylated calixarenes also proved effective at protection of CD69(high) lymphocytes from apoptosis triggered by a multivalent ligand or antibody. Thus, carboxylated calixarenes set a new paradigm for noncarbohydrate ligands for CD69 making them attractive for protection of killer cells in combined animal tumor therapies
    Trvalý link: http://hdl.handle.net/11104/0190625