Carboxylated calixarenes bind strongly to CD69 and protect CD69+ killer cells from suicidal cell death induced by tumor cell surface ligands

0350689 - MBÚ 2011 RIV GB eng J - Článek v odborném periodiku
Bezouška, K. - Šnajdrová, R. - Křenek, K. - Vančurová, Markéta - Kádek, A. - Adámek, D. - Lhoták, P. - Kavan, Daniel - Hofbauerová, Kateřina - Man, Petr - Bojarová, Pavla - Křen, Vladimír
Carboxylated calixarenes bind strongly to CD69 and protect CD69+ killer cells from suicidal cell death induced by tumor cell surface ligands.
Bioorganic & Medicinal Chemistry. Roč. 18, č. 4 (2010), s. 1434-1440. ISSN 0968-0896. E-ISSN 1464-3391
Grant CEP: GA MŠMT OC 136; GA MŠMT 1M0505; GA ČR GA303/09/0477; GA ČR GD305/09/H008; GA AV ČR IAA400200503; GA AV ČR KJB500200612
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: Carboxylated calixarenes * Lymphocyte activation * Receptor cross-linking
Kód oboru RIV: CE - Biochemie
Impakt faktor: 2.978, rok: 2010

We have recently identified a new class of high affinity ligands for CD69 leukocyte membrane receptor, carboxylated calixarenes. Of the three compounds investigated here, thiacalix[4]arene had the highest affinity for CD69 in direct binding assays, and proved to be the most specific inhibitor of CD69 identified so far in receptor precipitation and cellular activation experiments. Carboxylated calixarenes also proved effective at protection of CD69(high) lymphocytes from apoptosis triggered by a multivalent ligand or antibody. Thus, carboxylated calixarenes set a new paradigm for noncarbohydrate ligands for CD69 making them attractive for protection of killer cells in combined animal tumor therapies
Trvalý link: http://hdl.handle.net/11104/0190625