Počet záznamů: 1

Chronic Treatment with NGF Induces Spontaneous Fluctuations of Intracellular Ca(2+) in Icilin-Sensitive Dorsal Root Ganglion Neurons of the Rat

  1. 1.
    0349380 - UEM-P 2011 RIV JP eng J - Článek v odborném periodiku
    Kayano, T. - Kitamura, N. - Moriya, A. - Ozaki, Y. - Dayanithi, Govindan - Shibuya, I.
    Chronic Treatment with NGF Induces Spontaneous Fluctuations of Intracellular Ca(2+) in Icilin-Sensitive Dorsal Root Ganglion Neurons of the Rat.
    Journal of Veterinary Medical Science. Roč. 72, č. 12 (2010), s. 1531-1538 ISSN 0916-7250
    Výzkumný záměr: CEZ:AV0Z50390703
    Klíčová slova: capsaicin * sensory neuron * TRPA1
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 0.722, rok: 2010

    These results suggest that neurons expressing both capsaicin- and icilin-sensitive TRP channels are susceptible to NGF and become hyperexcitable and that Ca2+ influx through voltage-gated Ca2+ channels is the major source contributing to the [Ca2+)]i fluctuations. Since such DRG neurons could play a physiological role as nociceptors, the NGF-induced spontaneous activity of DRG neurons may be the underlying mechanism of neuropathic pain
    Trvalý link: http://hdl.handle.net/11104/0189636