Chronic Treatment with NGF Induces Spontaneous Fluctuations of Intracellular Ca(2+) in Icilin-Sensitive Dorsal Root Ganglion Neurons of the Rat

0349380 - ÚEM 2011 RIV JP eng J - Článek v odborném periodiku
Kayano, T. - Kitamura, N. - Moriya, A. - Ozaki, Y. - Dayanithi, Govindan - Shibuya, I.
Chronic Treatment with NGF Induces Spontaneous Fluctuations of Intracellular Ca(2+) in Icilin-Sensitive Dorsal Root Ganglion Neurons of the Rat.
Journal of Veterinary Medical Science. Roč. 72, č. 12 (2010), s. 1531-1538. ISSN 0916-7250. E-ISSN 1347-7439
Výzkumný záměr: CEZ:AV0Z50390703
Klíčová slova: capsaicin * sensory neuron * TRPA1
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 0.722, rok: 2010
http://arl-repository.lib.cas.cz/uloziste_av/UEM-P/cav_un_epca-0349380_01.pdf

These results suggest that neurons expressing both capsaicin- and icilin-sensitive TRP channels are susceptible to NGF and become hyperexcitable and that Ca2+ influx through voltage-gated Ca2+ channels is the major source contributing to the [Ca2+)]i fluctuations. Since such DRG neurons could play a physiological role as nociceptors, the NGF-induced spontaneous activity of DRG neurons may be the underlying mechanism of neuropathic pain
Trvalý link: http://hdl.handle.net/11104/0189636