Počet záznamů: 1

Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis

  1. 1.
    0341813 - FGU-C 2011 RIV US eng J - Článek v odborném periodiku
    Malínská, H. - Oliyarnyk, O. - Hubová, M. - Zídek, Václav - Landa, Vladimír - Šimáková, Miroslava - Mlejnek, Petr - Kazdová, L. - Kurtz, T. W. - Pravenec, Michal
    Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis.
    Molecular and Cellular Biochemistry. Roč. 335, 1-2 (2010), s. 119-125 ISSN 0300-8177
    Grant CEP: GA AV ČR(CZ) IAA500110604; GA MZd(CZ) NR9387; GA MZd(CZ) NR9359
    Grant ostatní: EC(XE) LSHG-CT-2005-019015
    Výzkumný záměr: CEZ:AV0Z50110509
    Klíčová slova: hepatic steatosis * oxidative stress * fatty acid composition
    Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
    Impakt faktor: 2.168, rok: 2010

    Increased liver oxidative stress and altered PUFA metabolism precede development of non-alcoholic steatohepatitis in SREBP-1a transgenic spontaneously hypertensive rats with genetic predisposition to hepatic steatosis.These results are consistent with the hypothesis that excess fat accumulation in the liver in association with increased oxidative stress and disturbances in the metabolism of saturated and unsaturated fatty acids may precede and contribute to the primary pathogenesis of NASH
    Trvalý link: http://hdl.handle.net/11104/0184686