Počet záznamů: 1

An iterative nonribosomal peptide synthetase assembles the pyrrole-amide antibiotic congocidine in Streptomyces ambofaciens

  1. 1.
    0334523 - MBU-M 2010 RIV US eng J - Článek v odborném periodiku
    Juguet, M. - Lautru, S. - Francou, F.-X. - Nezbedová, Šárka - Leblond, P. - Gondry, M. - Pernodet, J. L.
    An iterative nonribosomal peptide synthetase assembles the pyrrole-amide antibiotic congocidine in Streptomyces ambofaciens.
    Chemistry & Biology. Roč. 16, č. 4 (2009), s. 421-431 ISSN 1074-5521
    Výzkumný záměr: CEZ:AV0Z50200510
    Klíčová slova: ADENYLATION DOMAINS * ESCHERICHIA-COLI * FUNCTIONAL-ANALYSIS
    Kód oboru RIV: CE - Biochemie
    Impakt faktor: 6.523, rok: 2009

    The biosynthetic cluster directing the biosynthesis of the oligopyrol antibiotic congocidine was identified. For nine genes from the cluster it was possible to assign specific functions in congocidine biosynthesis, regulation or resistance. Further studies on its biosynthesis revealed that it is carried out by an iterative non-ribosomal peptide synthase that posses several original features
    Trvalý link: http://hdl.handle.net/11104/0179236