Počet záznamů: 1
An iterative nonribosomal peptide synthetase assembles the pyrrole-amide antibiotic congocidine in Streptomyces ambofaciens
- 1.0334523 - MBÚ 2010 RIV US eng J - Článek v odborném periodiku
Juguet, M. - Lautru, S. - Francou, F.-X. - Nezbedová, Šárka - Leblond, P. - Gondry, M. - Pernodet, J. L.
An iterative nonribosomal peptide synthetase assembles the pyrrole-amide antibiotic congocidine in Streptomyces ambofaciens.
Chemistry & Biology. Roč. 16, č. 4 (2009), s. 421-431. ISSN 1074-5521
Výzkumný záměr: CEZ:AV0Z50200510
Klíčová slova: ADENYLATION DOMAINS * ESCHERICHIA-COLI * FUNCTIONAL-ANALYSIS
Kód oboru RIV: CE - Biochemie
Impakt faktor: 6.523, rok: 2009
The biosynthetic cluster directing the biosynthesis of the oligopyrol antibiotic congocidine was identified. For nine genes from the cluster it was possible to assign specific functions in congocidine biosynthesis, regulation or resistance. Further studies on its biosynthesis revealed that it is carried out by an iterative non-ribosomal peptide synthase that posses several original features
Trvalý link: http://hdl.handle.net/11104/0179236
Počet záznamů: 1