Počet záznamů: 1
Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat
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SYSNO ASEP 0553221 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat Tvůrce(i) Pravenec, Michal (FGU-C) RID, ORCID
Šilhavý, Jan (FGU-C) RID, ORCID
Mlejnek, Petr (FGU-C) RID, ORCID
Šimáková, Miroslava (FGU-C) RID, ORCID
Mráček, Tomáš (FGU-C) RID, ORCID
Pecinová, Alena (FGU-C) RID, ORCID, SAI
Tauchmannová, Kateřina (FGU-C) RID, ORCID
Hüttl, M. (CZ)
Malínská, H. (CZ)
Kazdová, L. (CZ)
Neckář, Jan (FGU-C) RID, ORCID
Kolář, František (FGU-C) RID, ORCID, SAI
Žurmanová, J. (CZ)
Novotný, J. (CZ)
Houštěk, Josef (FGU-C) RID, ORCIDZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 70, Suppl.4 (2021), S471-S481Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova mitochondrial DNA ; conplastic strains ; spontaneously hypertensive rat ; glucose and lipid metabolism ; cardiac traits Obor OECD Physiology (including cytology) CEP GA19-10354S GA ČR - Grantová agentura ČR GA18-03207S GA ČR - Grantová agentura ČR GA17-07748S GA ČR - Grantová agentura ČR Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000768842600003 EID SCOPUS 85125098524 DOI 10.33549/physiolres.934740 Anotace Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the nucleus. Recently, natural mitochondrial genome (mtDNA) polymorphisms (haplogroups) received increasing attention in the pathophysiology of human common diseases. However, retrograde effects of mtDNA variants on such traits are difficult to study in humans. The conplastic strains represent key animal models to elucidate regulatory roles of mtDNA haplogroups on defined nuclear genome background. To analyze the relationship between mtDNA variants and cardiometabolic traits, we derived a set of rat conplastic strains (SHR-mtBN, SHR-mtF344 and SHR-mtLEW), harboring all major mtDNA haplotypes present in common inbred strains on the nuclear background of the spontaneously hypertensive rat (SHR). The BN, F344 and LEW mtDNA differ from the SHR in multiple amino acid substitutions in protein coding genes and also in variants of tRNA and rRNA genes. Different mtDNA haplotypes were found to predispose to various sets of cardiometabolic phenotypes which provided evidence for significant retrograde effects of mtDNA in the SHR. In the future, these animals could be used to decipher individual biochemical components involved in the retrograde signaling. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2022 Elektronická adresa https://www.biomed.cas.cz/physiolres/pdf/2021/70_S471.pdf
Počet záznamů: 1