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Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat

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    0553221 - FGÚ 2022 RIV CZ eng J - Článek v odborném periodiku
    Pravenec, Michal - Šilhavý, Jan - Mlejnek, Petr - Šimáková, Miroslava - Mráček, Tomáš - Pecinová, Alena - Tauchmannová, Kateřina - Hüttl, M. - Malínská, H. - Kazdová, L. - Neckář, Jan - Kolář, František - Žurmanová, J. - Novotný, J. - Houštěk, Josef
    Conplastic strains for identification of retrograde effects of mitochondrial dna variation on cardiometabolic traits in the spontaneously hypertensive rat.
    Physiological Research. Roč. 70, Suppl.4 (2021), S471-S481. ISSN 0862-8408. E-ISSN 1802-9973
    Grant CEP: GA ČR(CZ) GA19-10354S; GA ČR(CZ) GA18-03207S; GA ČR GA17-07748S
    Grant ostatní: AV ČR(CZ) StrategieAV21/7
    Program: StrategieAV
    Institucionální podpora: RVO:67985823
    Klíčová slova: mitochondrial DNA * conplastic strains * spontaneously hypertensive rat * glucose and lipid metabolism * cardiac traits
    Obor OECD: Physiology (including cytology)
    Impakt faktor: 1.881, rok: 2020
    Způsob publikování: Open access
    https://www.biomed.cas.cz/physiolres/pdf/2021/70_S471.pdf

    Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the nucleus. Recently, natural mitochondrial genome (mtDNA) polymorphisms (haplogroups) received increasing attention in the pathophysiology of human common diseases. However, retrograde effects of mtDNA variants on such traits are difficult to study in humans. The conplastic strains represent key animal models to elucidate regulatory roles of mtDNA haplogroups on defined nuclear genome background. To analyze the relationship between mtDNA variants and cardiometabolic traits, we derived a set of rat conplastic strains (SHR-mtBN, SHR-mtF344 and SHR-mtLEW), harboring all major mtDNA haplotypes present in common inbred strains on the nuclear background of the spontaneously hypertensive rat (SHR). The BN, F344 and LEW mtDNA differ from the SHR in multiple amino acid substitutions in protein coding genes and also in variants of tRNA and rRNA genes. Different mtDNA haplotypes were found to predispose to various sets of cardiometabolic phenotypes which provided evidence for significant retrograde effects of mtDNA in the SHR. In the future, these animals could be used to decipher individual biochemical components involved in the retrograde signaling.
    Trvalý link: http://hdl.handle.net/11104/0328219

     
     
Počet záznamů: 1