Počet záznamů: 1

Chelators for treatment of iron and copper overload: shift from low-molecular-weight compounds to polymers

SYSNO ASEP	0548168
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Chelators for treatment of iron and copper overload: shift from low-molecular-weight compounds to polymers
Tvůrce(i)	Hrubý, Martin (UMCH-V)_{RID, ORCID} Martínez, I. I. S. (DE) Stephan, H. (DE) Poučková, P. (CZ) Beneš, J. (CZ) Štěpánek, Petr (UMCH-V)_{RID, ORCID}
Číslo článku	3969
Zdroj.dok.	Polymers. - : MDPI Roč. 13, č. 22 (2021)
Poč.str.	21 s.
Jazyk dok.	eng - angličtina
Země vyd.	CH - Švýcarsko
Klíč. slova	iron ; copper ; polymer
Vědní obor RIV	CD - Makromolekulární chemie
Obor OECD	Polymer science
CEP	GA19-01438S GA ČR - Grantová agentura ČR
Způsob publikování	Open access
Institucionální podpora	UMCH-V - RVO:61389013
UT WOS	000724813200001
EID SCOPUS	85119718346
DOI	10.3390/polym13223969
Anotace	Iron and copper are essential micronutrients needed for the proper function of every cell. However, in excessive amounts, these elements are toxic, as they may cause oxidative stress, resulting in damage to the liver and other organs. This may happen due to poisoning, as a side effect of thalassemia infusion therapy or due to hereditary diseases hemochromatosis or Wilson’s disease. The current golden standard of therapy of iron and copper overload is the use of low-molecular-weight chelators of these elements. However, these agents suffer from severe side effects, are often expensive and possess unfavorable pharmacokinetics, thus limiting the usability of such therapy. The emerging concepts are polymer-supported iron- and copper-chelating therapeutics, either for parenteral or oral use, which shows vivid potential to keep the therapeutic efficacy of low-molecular-weight agents, while avoiding their drawbacks, especially their side effects. Critical evaluation of this new perspective polymer approach is the purpose of this review article.
Pracoviště	Ústav makromolekulární chemie
Kontakt	Eva Čechová, cechova@imc.cas.cz ; Tel.: 296 809 358
Rok sběru	2022
Elektronická adresa	https://www.mdpi.com/2073-4360/13/22/3969

Počet záznamů: 1