Chelators for treatment of iron and copper overload: shift from low-molecular-weight compounds to polymers

0548168 - ÚMCH 2022 RIV CH eng J - Článek v odborném periodiku
Hrubý, Martin - Martínez, I. I. S. - Stephan, H. - Poučková, P. - Beneš, J. - Štěpánek, Petr
Chelators for treatment of iron and copper overload: shift from low-molecular-weight compounds to polymers.
Polymers. Roč. 13, č. 22 (2021), č. článku 3969. E-ISSN 2073-4360
Grant CEP: GA ČR(CZ) GA19-01438S
Grant ostatní: AV ČR(CZ) DAAD-19-09; AV ČR(CZ) StrategieAV21/6
Program: Bilaterální spolupráce; StrategieAV
Institucionální podpora: RVO:61389013
Klíčová slova: iron * copper * polymer
Obor OECD: Polymer science
Impakt faktor: 4.967, rok: 2021
Způsob publikování: Open access
https://www.mdpi.com/2073-4360/13/22/3969

Iron and copper are essential micronutrients needed for the proper function of every cell. However, in excessive amounts, these elements are toxic, as they may cause oxidative stress, resulting in damage to the liver and other organs. This may happen due to poisoning, as a side effect of thalassemia infusion therapy or due to hereditary diseases hemochromatosis or Wilson’s disease. The current golden standard of therapy of iron and copper overload is the use of low-molecular-weight chelators of these elements. However, these agents suffer from severe side effects, are often expensive and possess unfavorable pharmacokinetics, thus limiting the usability of such therapy. The emerging concepts are polymer-supported iron- and copper-chelating therapeutics, either for parenteral or oral use, which shows vivid potential to keep the therapeutic efficacy of low-molecular-weight agents, while avoiding their drawbacks, especially their side effects. Critical evaluation of this new perspective polymer approach is the purpose of this review article.
Trvalý link: http://hdl.handle.net/11104/0325222