Počet záznamů: 1
Differences in Expression of Calcium Binding Proteins in the Perirhinal and Retrosplenial Cortex of the Rat
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SYSNO ASEP 0544075 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Differences in Expression of Calcium Binding Proteins in the Perirhinal and Retrosplenial Cortex of the Rat Tvůrce(i) Salaj, M. (CZ)
Barinka, F. (CZ)
Kubová, Hana (FGU-C) RID, ORCID
Druga, Rastislav (FGU-C) RID, ORCID, SAIZdroj.dok. Physiological Research. - : Fyziologický ústav AV ČR, v. v. i. - ISSN 0862-8408
Roč. 70, č. 2 (2021), s. 273-285Poč.str. 13 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova interneurons ; cortex ; calretinin ; parvalbumin Vědní obor RIV FH - Neurologie, neurochirurgie, neurovědy Obor OECD Neurosciences (including psychophysiology Způsob publikování Open access Institucionální podpora FGU-C - RVO:67985823 UT WOS 000672587800016 EID SCOPUS 85106593255 DOI 10.33549/physiolres.934548 Anotace The main aim was to describe interneuronal population expressing calcium binding proteins calretinin (CR) and parvalbumin (PV) in the perirhinal (PRC) and retrosplenial (RSC) cortex of the rat. These two cortical areas differ strikingly in their connectivity and function, which could be caused also by different structure of the interneuronal populations. Having a precise knowledge of the cellular composition of any cerebral area forms one of the basic input parameters and tenets for computational modelling of neuronal networks and for understanding some pathological conditions, like generating and spreading of epileptic activity. PRC possesses higher absolute and relative densities of CR+ and PV+ neurons than RSC, but the CR : PV ratio is higher in the RSC, which is similar to the neocortex. The bipolar/bitufted neurons are most common type of CR+ population, while the majority of PV+ neurons show multipolar morphology. Current results indicate that main difference between analysed areas is in density of CR+ neurons, which was significantly higher in the PRC. Our results coupled with works of other authors show that there are significant differences in the interneuronal composition and distribution of heretofore seemingly similar transitional cortical areas. These results may contribute to the better understanding of the mechanism of function of this cortical region in normal and diseased states. Pracoviště Fyziologický ústav Kontakt Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Rok sběru 2022 Elektronická adresa https://www.biomed.cas.cz/physiolres/pdf/2021/70_273.pdf
Počet záznamů: 1