Počet záznamů: 1
Differences in Expression of Calcium Binding Proteins in the Perirhinal and Retrosplenial Cortex of the Rat
- 1.0544075 - FGÚ 2022 RIV CZ eng J - Článek v odborném periodiku
Salaj, M. - Barinka, F. - Kubová, Hana - Druga, Rastislav
Differences in Expression of Calcium Binding Proteins in the Perirhinal and Retrosplenial Cortex of the Rat.
Physiological Research. Roč. 70, č. 2 (2021), s. 273-285. ISSN 0862-8408. E-ISSN 1802-9973
Institucionální podpora: RVO:67985823
Klíčová slova: interneurons * cortex * calretinin * parvalbumin
Obor OECD: Neurosciences (including psychophysiology
Impakt faktor: 2.139, rok: 2021
Způsob publikování: Open access
The main aim was to describe interneuronal population expressing calcium binding proteins calretinin (CR) and parvalbumin (PV) in the perirhinal (PRC) and retrosplenial (RSC) cortex of the rat. These two cortical areas differ strikingly in their connectivity and function, which could be caused also by different structure of the interneuronal populations. Having a precise knowledge of the cellular composition of any cerebral area forms one of the basic input parameters and tenets for computational modelling of neuronal networks and for understanding some pathological conditions, like generating and spreading of epileptic activity. PRC possesses higher absolute and relative densities of CR+ and PV+ neurons than RSC, but the CR : PV ratio is higher in the RSC, which is similar to the neocortex. The bipolar/bitufted neurons are most common type of CR+ population, while the majority of PV+ neurons show multipolar morphology. Current results indicate that main difference between analysed areas is in density of CR+ neurons, which was significantly higher in the PRC. Our results coupled with works of other authors show that there are significant differences in the interneuronal composition and distribution of heretofore seemingly similar transitional cortical areas. These results may contribute to the better understanding of the mechanism of function of this cortical region in normal and diseased states.
Trvalý link: http://hdl.handle.net/11104/0321132
Počet záznamů: 1