Počet záznamů: 1
ESI-TOF Mass Spectrometry of Cationic Carbosilane Dendrimers: a Potent Tool for Characterization of Structural Defects.
- 1.
SYSNO ASEP 0494758 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název ESI-TOF Mass Spectrometry of Cationic Carbosilane Dendrimers: a Potent Tool for Characterization of Structural Defects. Tvůrce(i) Cuřínová, Petra (UCHP-M) RID, SAI, ORCID
Krupková, Alena (UCHP-M) RID, ORCID, SAI
Červenková Šťastná, Lucie (UCHP-M) RID, ORCID, SAI
Müllerová, Monika (UCHP-M) RID, ORCID, SAI
Čermák, Jan (UCHP-M) RID, ORCID, SAI
Strašák, Tomáš (UCHP-M) RID, ORCID, SAIZdroj.dok. Journal of Mass Spectrometry. - : Wiley - ISSN 1076-5174
Roč. 53, č. 10 (2018), s. 986-996Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova carbosilane dendrimers ; ESI mass spectrometry ; defect analysis Vědní obor RIV CB - Analytická chemie, separace Obor OECD Analytical chemistry CEP GA15-05903S GA ČR - Grantová agentura ČR Institucionální podpora UCHP-M - RVO:67985858 UT WOS 000446836600010 EID SCOPUS 85052430394 DOI 10.1002/jms.4269 Anotace Macromolecular polyelectrolytes are gaining considerable attention for the application in medicine which implies their detailed characterization. We have successfully applied electrospray ionization mass spectrometry (ESI MS) to the analysis of defects in the structure of three generations of polycationic carbosilane dendrimers bearing series of quarternary phosphonium groups at their periphery. Besides expected defects caused by incomplete conversion of particular reaction steps during the synthesis of dendritic scaffold and subsequent peripheral functionalization, also several products of side reactions were observed together with defects created in the course of measurement (particularly ion exchange products). Defective molecules can be to some extent separated on GPC column which proves that they are not products of in source fragmentation processes. Within the reaction sequence used for the synthesis of dendrimers under study, hydrosilylation was the source of most defects. The effectivity of quarternization depends on the type of phosphine. Results confirm high sensitivity of ESI MS towards defects, stability of the carbosilane skeleton towards fragmentation under the conditions of ESI ionization and capability to detect both lower‐ and higher molecular weight impurities arising from the synthetic sequence in the same m/z range as the target dendrimer, thus providing valuable view of the polydispersity. Pracoviště Ústav chemických procesů Kontakt Eva Jirsová, jirsova@icpf.cas.cz, Tel.: 220 390 227 Rok sběru 2019
Počet záznamů: 1