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Meet interesting abbreviations in clinical mass spectrometry: from compound classification by REIMS to multimodal and mass spectrometry imaging (MSI)
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SYSNO ASEP 0479451 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Meet interesting abbreviations in clinical mass spectrometry: from compound classification by REIMS to multimodal and mass spectrometry imaging (MSI) Tvůrce(i) Luptáková, Dominika (MBU-M) ORCID, RID
Pluháček, Tomáš (MBU-M) ORCID
Palyzová, Andrea (MBU-M) RID, ORCID
Přichystal, Jakub (MBU-M)
Balogh, J. (HU)
Lemr, Karel (MBU-M) RID, ORCID
Juránek, I. (SK)
Havlíček, Vladimír (MBU-M) RID, ORCIDZdroj.dok. Acta virologica - ISSN 0001-723X
Roč. 61, č. 3 (2017), s. 353-360Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. SK - Slovensko Klíč. slova REIMS ; multimodal ; mass spectrometry imaging Vědní obor RIV EE - Mikrobiologie, virologie Obor OECD Microbiology CEP LO1509 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy GA16-20229S GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000411298700017 EID SCOPUS 85028622286 DOI 10.4149/av_2017_316 Anotace This feature article discusses two modern mass spectrometry abbreviations in their clinical applications. Rapid evaporative ionization mass spectrometry (REIMS) is reported as a molecular classification tool useful for spectral features definition prior to mass spectrometry imaging (MSI). REIMS is appreciated not only as an ionization technique coupled with a surgical device but particularly as a biomarker discovery tool. For more complex understanding of pathological processes at cellular and molecular levels, the importance of multimodal approach in imaging applications is documented in the context of fiducial markers needed for hyperspectral data fusion collected by optical microscopy, elemental and molecular MSI. Finally, pathogen inactivation needed prior to the sectioning of the infected tissue is reported, and the impact of formaldehyde crosslinking to signal reduction is discussed. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2018
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