Počet záznamů: 1  

Meet interesting abbreviations in clinical mass spectrometry: from compound classification by REIMS to multimodal and mass spectrometry imaging (MSI)

  1. 1.
    0479451 - MBÚ 2018 RIV SK eng J - Článek v odborném periodiku
    Luptáková, Dominika - Pluháček, Tomáš - Palyzová, Andrea - Přichystal, Jakub - Balogh, J. - Lemr, Karel - Juránek, I. - Havlíček, Vladimír
    Meet interesting abbreviations in clinical mass spectrometry: from compound classification by REIMS to multimodal and mass spectrometry imaging (MSI).
    Acta virologica. Roč. 61, č. 3 (2017), s. 353-360. ISSN 0001-723X
    Grant CEP: GA MŠk(CZ) LO1509; GA ČR(CZ) GA16-20229S
    Institucionální podpora: RVO:61388971
    Klíčová slova: REIMS * multimodal * mass spectrometry imaging
    Kód oboru RIV: EE - Mikrobiologie, virologie
    Obor OECD: Microbiology
    Impakt faktor: 0.696, rok: 2017

    This feature article discusses two modern mass spectrometry abbreviations in their clinical applications. Rapid evaporative ionization mass spectrometry (REIMS) is reported as a molecular classification tool useful for spectral features definition prior to mass spectrometry imaging (MSI). REIMS is appreciated not only as an ionization technique coupled with a surgical device but particularly as a biomarker discovery tool. For more complex understanding of pathological processes at cellular and molecular levels, the importance of multimodal approach in imaging applications is documented in the context of fiducial markers needed for hyperspectral data fusion collected by optical microscopy, elemental and molecular MSI. Finally, pathogen inactivation needed prior to the sectioning of the infected tissue is reported, and the impact of formaldehyde crosslinking to signal reduction is discussed.
    Trvalý link: http://hdl.handle.net/11104/0275441