Počet záznamů: 1
Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd
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SYSNO ASEP 0458543 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd Tvůrce(i) Chukwujekwu, J. C. (ZA)
Rengasamy, K.R.R. (ZA)
de Kock, C. A. (ZA)
Smith, P. J. (ZA)
Poštová Slavětínská, Lenka (UOCHB-X) RID
van Staden, J. (ZA)Zdroj.dok. Journal of Enzyme Inhibition and Medicinal Chemistry. - : Taylor & Francis - ISSN 1475-6366
Roč. 31, č. 1 (2016), s. 63-66Poč.str. 4 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova alpha-glucosidase ; antidiabetic ; antiplasmodial ; Buddleja saligna ; terpenoids Vědní obor RIV CC - Organická chemie Institucionální podpora UOCHB-X - RVO:61388963 UT WOS 000367555300007 EID SCOPUS 84953292273 DOI 10.3109/14756366.2014.1003927 Anotace In our continuing search for biologically active natural product(s) of plant origin, Buddleja saligna, a South African medicinal plant, was screened in line with its traditional use for antidiabetic (yeast alpha glucosidase inhibitory) and antiplasmodial (against a chloroquine sensitive strain of Plasmodium falciparum (NF54)) activities. The hexane fraction showed the most promising activity with regards to its antidiabetic (IC50=260 +/- 0.112 mu g/ml) and antiplasmodial (IC50=8.5 +/- 1.6 mu g/ml) activities. Using activity guided fractionation three known terpenoids (betulonic acid, betulone and spinasterol) were isolated from this species for the first time. The compounds displayed varying levels of biological activities (antidiabetic: 27.31 mu g/ml >= C-50 >= 5.6 mu g/ml; antiplasmodial: 14 mu g/ml >= C-50 >= 2 mu g/ml) with very minimal toxicity. Pracoviště Ústav organické chemie a biochemie Kontakt asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Viktorie Chládková, Tel.: 232 002 434 Rok sběru 2017
Počet záznamů: 1