Počet záznamů: 1  

Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd

  1. 1.
    0458543 - UOCHB-X 2017 RIV GB eng J - Článek v odborném periodiku
    Chukwujekwu, J. C. - Rengasamy, K.R.R. - de Kock, C. A. - Smith, P. J. - Poštová Slavětínská, Lenka - van Staden, J.
    Alpha-glucosidase inhibitory and antiplasmodial properties of terpenoids from the leaves of Buddleja saligna Willd.
    Journal of Enzyme Inhibition and Medicinal Chemistry. Roč. 31, č. 1 (2016), s. 63-66. ISSN 1475-6366
    Institucionální podpora: RVO:61388963
    Klíčová slova: alpha-glucosidase * antidiabetic * antiplasmodial * Buddleja saligna * terpenoids
    Kód oboru RIV: CC - Organická chemie
    Impakt faktor: 4.293, rok: 2016

    In our continuing search for biologically active natural product(s) of plant origin, Buddleja saligna, a South African medicinal plant, was screened in line with its traditional use for antidiabetic (yeast alpha glucosidase inhibitory) and antiplasmodial (against a chloroquine sensitive strain of Plasmodium falciparum (NF54)) activities. The hexane fraction showed the most promising activity with regards to its antidiabetic (IC50=260 +/- 0.112 mu g/ml) and antiplasmodial (IC50=8.5 +/- 1.6 mu g/ml) activities. Using activity guided fractionation three known terpenoids (betulonic acid, betulone and spinasterol) were isolated from this species for the first time. The compounds displayed varying levels of biological activities (antidiabetic: 27.31 mu g/ml >= C-50 >= 5.6 mu g/ml; antiplasmodial: 14 mu g/ml >= C-50 >= 2 mu g/ml) with very minimal toxicity.
    Trvalý link: http://hdl.handle.net/11104/0258804