Počet záznamů: 1  

High-frequency oscillations and seizure activity and in the human anterior nucleus of the thalamus

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    SYSNO ASEP0455709
    Druh ASEPA - Abstrakt
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    NázevHigh-frequency oscillations and seizure activity and in the human anterior nucleus of the thalamus
    Tvůrce(i) Rektor, I. (CZ)
    Doležalová, I. (CZ)
    Chrastina, J. (CZ)
    Jurák, Pavel (UPT-D) RID, ORCID, SAI
    Halámek, Josef (UPT-D) RID, ORCID, SAI
    Brázdil, M. (CZ)
    Celkový počet autorů6
    Zdroj.dok.Epilepsia - ISSN 0013-9580
    Roč. 56, S1 (2015), s. 29-30
    Poč.str.2 s.
    Forma vydáníOnline - E
    AkceInternational Epilepsy Congress /31./
    Datum konání05.09.2015-09.09.2015
    Místo konáníIstanbul
    ZeměTR - Turecko
    Typ akceWRD
    Jazyk dok.eng - angličtina
    Země vyd.US - Spojené státy americké
    Klíč. slovahigh-frequency oscillations ; anterior nucleus of the thalamus
    Vědní obor RIVFS - Lékařská zařízení, přístroje a vybavení
    Institucionální podporaUPT-D - RVO:68081731
    AnotaceDeep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) has recently been introduced into therapy for refractory epilepsy. The role played by the ANT in human epileptic seizures and the mechanisms leading to the anti-seizure effects of ANT-DBS have not yet been fully elucidated. This is the first report of recording interictal and ictal activity in the human ANT. DBS electrodes were implanted in the ANT of six pharma- coresistent patients with temporal and extratemporal epilepsies who had not responded to vagus nerve stimulation. Interictal and ictal video-EEG was recorded via the DBS electrodes before the electrodes were internalized and a neurostimulation device was implanted. Interictal high frequency oscillations (HFO) of 80 to 240 Hz, in one case of 500 Hz, were recorded in four patients. Eight clinical seizures in four patients were recorded; a robust broad-band increase of power occurred in the early phases of all seizures. In two patients, the ictal changes preceded the clinical symptoms. No interictal epileptiform discharges were recorded; early epileptiform pattern preceding the clinical onset was recorded in one seizure.Based on our recordings of HFO, of early ictal EEG modifications, and of occurrences of ictal epileptiform pattern, we suggest that the ANT may participate actively in the network elaborating seizures in human epilepsies.
    PracovištěÚstav přístrojové techniky
    KontaktJan Slaměník, jan@isibrno.cz, Tel.: 541 514 205 ; Miluše Langová, langova@isibrno.cz
    Rok sběru2016