Počet záznamů: 1  

High-frequency oscillations and seizure activity and in the human anterior nucleus of the thalamus

  1. 1.
    0455709 - UPT-D 2016 US eng A - Abstrakt
    Rektor, I. - Doležalová, I. - Chrastina, J. - Jurák, Pavel - Halámek, Josef - Brázdil, M.
    High-frequency oscillations and seizure activity and in the human anterior nucleus of the thalamus.
    Epilepsia. Roč. 56, S1 (2015), s. 29-30. ISSN 0013-9580.
    [International Epilepsy Congress /31./. 05.09.2015-09.09.2015, Istanbul]
    Institucionální podpora: RVO:68081731
    Klíčová slova: high-frequency oscillations * anterior nucleus of the thalamus
    Kód oboru RIV: FS - Lékařská zařízení, přístroje a vybavení

    Deep brain stimulation of the anterior nucleus of the thalamus (ANT-DBS) has recently been introduced into therapy for refractory epilepsy. The role played by the ANT in human epileptic seizures and the mechanisms leading to the anti-seizure effects of ANT-DBS have not yet been fully elucidated. This is the first report of recording interictal and ictal activity in the human ANT. DBS electrodes were implanted in the ANT of six pharma- coresistent patients with temporal and extratemporal epilepsies who had not responded to vagus nerve stimulation. Interictal and ictal video-EEG was recorded via the DBS electrodes before the electrodes were internalized and a neurostimulation device was implanted. Interictal high frequency oscillations (HFO) of 80 to 240 Hz, in one case of 500 Hz, were recorded in four patients. Eight clinical seizures in four patients were recorded; a robust broad-band increase of power occurred in the early phases of all seizures. In two patients, the ictal changes preceded the clinical symptoms. No interictal epileptiform discharges were recorded; early epileptiform pattern preceding the clinical onset was recorded in one seizure.Based on our recordings of HFO, of early ictal EEG modifications, and of occurrences of ictal epileptiform pattern, we suggest that the ANT may participate actively in the network elaborating seizures in human epilepsies.
    Trvalý link: http://hdl.handle.net/11104/0256337