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Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery
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SYSNO ASEP 0372287 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery Tvůrce(i) Kejík, Z. (CZ)
Bříza, T. (CZ)
Králová, Jarmila (UMG-J) RID
Poučková, P. (CZ)
Kral, A. (CZ)
Martásek, P. (CZ)
Král, V. (CZ)Zdroj.dok. Bioorganic and Medicinal Chemistry Letters. - : Elsevier - ISSN 0960-894X
Roč. 21, č. 18 (2011), s. 5514-5520Poč.str. 7 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova combined cancer therapy ; photodynamic therapy ; targeted drug delivery Vědní obor RIV EB - Genetika a molekulární biologie CEP GA203/09/1311 GA ČR - Grantová agentura ČR CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000294051800080 DOI 10.1016/j.bmcl.2011.06.101 Anotace We present here a general system for the coordination attachment of therapeutic proteins to a drug delivery system and its application in combined therapy. Proof of concept is demonstrated by the synthesis and testing of the targeted drug delivery system for cytostatics, which is based on a combination of the drug carrier Zn-porphyrin-cyclodextrin conjugates and their supramolecular coordination complexes with immunoglobulins. This system can be as readily used for a variety of therapeutic and targeting proteins including PAs, MAs, lectins, and HSA. Moreover, it allows combined photodynamic therapy, cell targeted chemotherapy and immunotherapy. When tested in a mouse model with human C32 carcinoma, the therapeutic superiority of the coordination assembly nanosystem was shown in comparison with the efficacy of building blocks used for the construction of the system. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2012
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