Počet záznamů: 1  

Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery

  1. 1. 0372287 - UMG-J 2012 RIV GB eng J - Článek v odborném periodiku
    Kejík, Z. - Bříza, T. - Králová, Jarmila - Poučková, P. - Kral, A. - Martásek, P. - Král, V.
    Coordination conjugates of therapeutic proteins with drug carriers: A new approach for versatile advanced drug delivery.
    Bioorganic and Medicinal Chemistry Letters. Roč. 21, č. 18 (2011), s. 5514-5520 ISSN 0960-894X
    Grant CEP: GA ČR GA203/09/1311
    Grant ostatní:MPO(CZ) FR-TI3/521; AV ČR(CZ) KAN200100801
    Program:FR; KA
    Výzkumný záměr: CEZ:AV0Z50520514
    Klíčová slova: combined cancer therapy * photodynamic therapy * targeted drug delivery
    Kód oboru RIV: EB - Genetika a molekulární biologie
    Impakt faktor: 2.554, rok: 2011

    We present here a general system for the coordination attachment of therapeutic proteins to a drug delivery system and its application in combined therapy. Proof of concept is demonstrated by the synthesis and testing of the targeted drug delivery system for cytostatics, which is based on a combination of the drug carrier Zn-porphyrin-cyclodextrin conjugates and their supramolecular coordination complexes with immunoglobulins. This system can be as readily used for a variety of therapeutic and targeting proteins including PAs, MAs, lectins, and HSA. Moreover, it allows combined photodynamic therapy, cell targeted chemotherapy and immunotherapy. When tested in a mouse model with human C32 carcinoma, the therapeutic superiority of the coordination assembly nanosystem was shown in comparison with the efficacy of building blocks used for the construction of the system.
    Trvalý link: http://hdl.handle.net/11104/0205641