Počet záznamů: 1
Expression and characterization of c-Myb in prenatal odontogenesis
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SYSNO ASEP 0368272 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Expression and characterization of c-Myb in prenatal odontogenesis Tvůrce(i) Matalová, Eva (UZFG-Y) RID
Buchtová, Marcela (UZFG-Y) RID, ORCID
Tucker, A. S. (GB)
Bender, T. P. (US)
Janečková, Eva (UZFG-Y)
Lungová, V. (CZ)
Balková, Simona (UZFG-Y)
Šmarda, J. (CZ)Celkový počet autorů 8 Zdroj.dok. Development Growth & Differentiation - ISSN 0012-1592
Roč. 53, č. 6 (2011), s. 793-803Poč.str. 11 s. Jazyk dok. eng - angličtina Země vyd. JP - Japonsko Klíč. slova morphogenesis ; mouse ; Myb Vědní obor RIV FF - ORL, oftalmologie, stomatologie CEP KJB500450802 GA AV ČR - Akademie věd GAP304/11/1418 GA ČR - Grantová agentura ČR GP304/08/P289 GA ČR - Grantová agentura ČR GC524/08/J032 GA ČR - Grantová agentura ČR CEZ AV0Z50450515 - UZFG-Y (2005-2011) UT WOS 000293902200004 DOI 10.1111/j.1440-169X.2011.01287.x Anotace The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis. Pracoviště Ústav živočišné fyziologie a genetiky Kontakt Jana Zásmětová, knihovna@iapg.cas.cz, Tel.: 315 639 554 Rok sběru 2012
Počet záznamů: 1