Expression and characterization of c-Myb in prenatal odontogenesis

0368272 - ÚŽFG 2012 RIV JP eng J - Článek v odborném periodiku
Matalová, Eva - Buchtová, Marcela - Tucker, A. S. - Bender, T. P. - Janečková, Eva - Lungová, V. - Balková, Simona - Šmarda, J.
Expression and characterization of c-Myb in prenatal odontogenesis.
Development Growth & Differentiation. Roč. 53, č. 6 (2011), s. 793-803. ISSN 0012-1592. E-ISSN 1440-169X
Grant CEP: GA AV ČR KJB500450802; GA ČR GAP304/11/1418; GA ČR(CZ) GP304/08/P289; GA ČR GC524/08/J032
Výzkumný záměr: CEZ:AV0Z50450515
Klíčová slova: morphogenesis * mouse * Myb
Kód oboru RIV: FF - ORL, oftalmologie, stomatologie
Impakt faktor: 2.210, rok: 2011

The transcription factor c-Myb is involved in the control of cell proliferation, survival and differentiation. As these processes accompany the morphogenesis of developing teeth, this work investigates the possible role of c-Myb during odontogenesis. Analysis of the expression of c-Myb in the monophyodont mouse was followed by similar analysis in a diphyodont species, the pig, which has a dentition more closely resembling that of the human. The distribution of c-Myb was correlated with the pattern of proliferation and apoptosis and the tooth phenotype of c-Myb mutant mice was also assessed. In the mouse, c-Myb expression was detected throughout prenatal development of the first molar tooth. Negative temporospatial correlation was found between c-Myb expression and apoptosis, while c-Myb expression positively correlated with proliferation. c-Myb-positive cells, however, were more abundant than the proliferating cell nuclear antigen positive cells, suggesting other roles of c-Myb in odontogenesis.
Trvalý link: http://hdl.handle.net/11104/0202663