Počet záznamů: 1

Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects

SYSNO ASEP	0350388
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects
Tvůrce(i)	Hála, Michal (UEB-Q)_{RID, ORCID} Soukupová, Hana (UEB-Q)_{RID, ORCID} Synek, Lukáš (UEB-Q)_{RID, ORCID} Žárský, Viktor (UEB-Q)_{RID, ORCID}
Zdroj.dok.	Plant Journal. - : Wiley - ISSN 0960-7412 Roč. 62, č. 4 (2010), s. 615-627
Poč.str.	13 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	RAB GTPases ; cell expansion ; photomorphogenesis
Vědní obor RIV	EA - Morfologické obory a cytologie
CEP	GP204/06/P467 GA ČR - Grantová agentura ČR
	KJB600380802 GA AV ČR - Akademie věd
CEZ	AV0Z50380511 - UEB-Q (2005-2011)
UT WOS	000277609500007
DOI	10.1111/j.1365-313X.2010.04172.x
Anotace	RAB GTPases are key regulators of intracellular vesicle transport. They are modified by geranylgeranylation catalyzed by the RAB geranylgeranyl transferase (RAB-GGT). Here, we show that RAB-GGT activity is significantly reduced in two homozygous mutants of the major Arabidopsis beta-subunit of RAB-GGT (AtRGTB1), resulting in unprenylated RAB GTPases accumulation in the cytoplasm. Both endocytosis and exocytosis are downregulated in rgtb1 homozygotes defective in shoot growth and morphogenesis. Root gravitropism is normal in rgtb1 roots, but is significantly compromised in shoots. Mutants are defective in etiolation and show constitutive photomorphogenic phenotypes that cannot be rescued by brassinosteroid treatment, similarly to the secretory det3 mutant. Transcriptomic analysis revealed an upregulation of specific RAB GTPases in etiolated wild-type plants. These data suggest that the downregulation of the secretory pathway is interpreted as a photomorphogenic signal in Arabidopsis.
Pracoviště	Ústav experimentální botaniky
Kontakt	David Klier, knihovna@ueb.cas.cz, Tel.: 220 390 469
Rok sběru	2011

Počet záznamů: 1