Počet záznamů: 1  

Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects

  1. 1.
    0350388 - ÚEB 2011 RIV GB eng J - Článek v odborném periodiku
    Hála, Michal - Soukupová, Hana - Synek, Lukáš - Žárský, Viktor
    Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects.
    Plant Journal. Roč. 62, č. 4 (2010), s. 615-627. ISSN 0960-7412. E-ISSN 1365-313X
    Grant CEP: GA ČR GP204/06/P467; GA AV ČR KJB600380802
    Výzkumný záměr: CEZ:AV0Z50380511
    Klíčová slova: RAB GTPases * cell expansion * photomorphogenesis
    Kód oboru RIV: EA - Morfologické obory a cytologie
    Impakt faktor: 6.948, rok: 2010

    RAB GTPases are key regulators of intracellular vesicle transport. They are modified by geranylgeranylation catalyzed by the RAB geranylgeranyl transferase (RAB-GGT). Here, we show that RAB-GGT activity is significantly reduced in two homozygous mutants of the major Arabidopsis beta-subunit of RAB-GGT (AtRGTB1), resulting in unprenylated RAB GTPases accumulation in the cytoplasm. Both endocytosis and exocytosis are downregulated in rgtb1 homozygotes defective in shoot growth and morphogenesis. Root gravitropism is normal in rgtb1 roots, but is significantly compromised in shoots. Mutants are defective in etiolation and show constitutive photomorphogenic phenotypes that cannot be rescued by brassinosteroid treatment, similarly to the secretory det3 mutant. Transcriptomic analysis revealed an upregulation of specific RAB GTPases in etiolated wild-type plants. These data suggest that the downregulation of the secretory pathway is interpreted as a photomorphogenic signal in Arabidopsis.
    Trvalý link: http://hdl.handle.net/11104/0190404

     
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