Počet záznamů: 1

Use of the Leksell Gamma Knife in the Treatment of Prolactinoma Patients

SYSNO ASEP	0337772
Druh ASEP	J - Článek v odborném periodiku
Zařazení RIV	J - Článek v odborném periodiku
Poddruh J	Článek ve WOS
Název	Use of the Leksell Gamma Knife in the Treatment of Prolactinoma Patients
Tvůrce(i)	Ježková, J. (CZ) Hána, V. (CZ) Kršek, M. (CZ) Weiss, V. (CZ) Vladyka, V. (CZ) Liščák, R. (CZ) Vymazal, J. (CZ) Pecen, Ladislav (UIVT-O)_{RID, SAI, ORCID} Marek, J. (CZ)
Zdroj.dok.	Clinical Endocrinology - ISSN 0300-0664 Roč. 70, č. 5 (2009), s. 732-741
Poč.str.	10 s.
Jazyk dok.	eng - angličtina
Země vyd.	GB - Velká Británie
Klíč. slova	prolactinoma ; Leksell gamma knife ; time to prolactin normalization analysis
Vědní obor RIV	FB - Endokrinologie, diabetologie, metabolizmus, výživa
CEZ	AV0Z10300504 - UIVT-O (2005-2011)
UT WOS	000264563800012
EID SCOPUS	63149148886
DOI	10.1111/j.1365-2265.2008.03384.x
Anotace	Pharmacological with dopaminergic agonists (DA), surgical and radiation treatments are the choices for prolactinomas. We describe 12-year experience in treating prolactinomas with the Leksell gamma knife (LGK). We followed 35 prolactinoma patients treated with LGK. Prior to LGK patients were treated with DA and 29% underwent neurosurgery. Indications for LGK were: DA intolerance (31%), DA resistance (46%) and efforts to reduce the DA dose (23%). Pituitary function was monitored regularly at 6m intervals. Normoprolactinaemia was achieved in 37% of the patients who discontinued DA and in 43% of patients who continued DA treatment after LGK irradiation. The median time to prolactin normalization after discontinuation of DA was 96m. After LGK the prolactinoma stopped growing or decreased in size in all but one patient (97%). LGK treatment resulted in normoprolactinaemia in 80% of the patients, all of whom had failed pharmacological treatment due to DA resistance or intolerance.
Pracoviště	Ústav informatiky
Kontakt	Tereza Šírová, sirova@cs.cas.cz, Tel.: 266 053 800
Rok sběru	2010

Počet záznamů: 1