Use of the Leksell Gamma Knife in the Treatment of Prolactinoma Patients

0337772 - ÚI 2010 RIV GB eng J - Článek v odborném periodiku
Ježková, J. - Hána, V. - Kršek, M. - Weiss, V. - Vladyka, V. - Liščák, R. - Vymazal, J. - Pecen, Ladislav - Marek, J.
Use of the Leksell Gamma Knife in the Treatment of Prolactinoma Patients.
Clinical Endocrinology. Roč. 70, č. 5 (2009), s. 732-741. ISSN 0300-0664. E-ISSN 1365-2265
Výzkumný záměr: CEZ:AV0Z10300504
Klíčová slova: prolactinoma * Leksell gamma knife * time to prolactin normalization analysis
Kód oboru RIV: FB - Endokrinologie, diabetologie, metabolizmus, výživa
Impakt faktor: 3.201, rok: 2009

Pharmacological with dopaminergic agonists (DA), surgical and radiation treatments are the choices for prolactinomas. We describe 12-year experience in treating prolactinomas with the Leksell gamma knife (LGK). We followed 35 prolactinoma patients treated with LGK. Prior to LGK patients were treated with DA and 29% underwent neurosurgery. Indications for LGK were: DA intolerance (31%), DA resistance (46%) and efforts to reduce the DA dose (23%). Pituitary function was monitored regularly at 6m intervals. Normoprolactinaemia was achieved in 37% of the patients who discontinued DA and in 43% of patients who continued DA treatment after LGK irradiation. The median time to prolactin normalization after discontinuation of DA was 96m. After LGK the prolactinoma stopped growing or decreased in size in all but one patient (97%). LGK treatment resulted in normoprolactinaemia in 80% of the patients, all of whom had failed pharmacological treatment due to DA resistance or intolerance.
Trvalý link: http://hdl.handle.net/11104/0181696