Počet záznamů: 1
Signalling activated by the death receptors of the TNRF family
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SYSNO ASEP 0333976 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Signalling activated by the death receptors of the TNRF family Tvůrce(i) Anděra, Ladislav (UMG-J) RID Celkový počet autorů 1 Zdroj.dok. Biomedical Papers. - : Univerzita Palackého v Olomouci - ISSN 1213-8118
Roč. 153, č. 3 (2009), s. 173-180Poč.str. 8 s. Jazyk dok. eng - angličtina Země vyd. CZ - Česká republika Klíč. slova death receptors ; apoptosis ; signaling Vědní obor RIV EB - Genetika a molekulární biologie CEP 1M0506 GA MŠMT - Ministerstvo školství, mládeže a tělovýchovy CEZ AV0Z50520514 - UMG-J (2005-2011) UT WOS 000270808400001 Anotace Among the most prominent players in the field of the extracellular signals leading to cell death, preferentially through induction of apoptosis belong several receptors from so-called Death Receptors group of the Tumour Necrosis Factors Receptors (TNFR) family. Over 15 years of the research on activation and regulation of the most prominent member of this group – receptors for the ligands TRAIL, FasL and TNFa brought not only a detail (and still refining) mechanism of these receptors activation and downstream signaling, but also connected them with the ultimate apoptotic gatekeeper – mitochondria. However, in addition to the pro-death signaling, these receptors were also shown under certain circumstances to activate an opposite, pro-proliferative signaling as well as to participate in pro-inflammatory responses. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2010
Počet záznamů: 1