Signalling activated by the death receptors of the TNRF family

0333976 - ÚMG 2010 RIV CZ eng J - Článek v odborném periodiku
Anděra, Ladislav
Signalling activated by the death receptors of the TNRF family.
Biomedical Papers. Roč. 153, č. 3 (2009), s. 173-180. ISSN 1213-8118. E-ISSN 1804-7521
Grant CEP: GA MŠMT 1M0506
Grant ostatní: AV ČR(CZ) KAN200520703
Program: KA
Výzkumný záměr: CEZ:AV0Z50520514
Klíčová slova: death receptors * apoptosis * signaling
Kód oboru RIV: EB - Genetika a molekulární biologie

Among the most prominent players in the field of the extracellular signals leading to cell death, preferentially through induction of apoptosis belong several receptors from so-called Death Receptors group of the Tumour Necrosis Factors Receptors (TNFR) family. Over 15 years of the research on activation and regulation of the most prominent member of this group – receptors for the ligands TRAIL, FasL and TNFa brought not only a detail (and still refining) mechanism of these receptors activation and downstream signaling, but also connected them with the ultimate apoptotic gatekeeper – mitochondria. However, in addition to the pro-death signaling, these receptors were also shown under certain circumstances to activate an opposite, pro-proliferative signaling as well as to participate in pro-inflammatory responses.
Trvalý link: http://hdl.handle.net/11104/0178826