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Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis
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SYSNO ASEP 0031432 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Ostatní články Název Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis Překlad názvu Genetická susceptibilita k infekčním chorobám: pohled z myších modelů leishmaniázy Tvůrce(i) Lipoldová, Marie (UMG-J) RID
Demant, P. (US)Zdroj.dok. Nature Reviews Genetics - ISSN 1471-0056
Roč. 7, č. 4 (2006), s. 294-305Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. GB - Velká Británie Klíč. slova leishmaniasis ; susceptibility to infectious disease ; modifying genes Vědní obor RIV EB - Genetika a molekulární biologie CEP GA310/03/1381 GA ČR - Grantová agentura ČR CEZ AV0Z50520514 - UMG-J (2005-2011) Anotace Susceptibility to infectious disease is influenced by multiple host genes, most of which are low penetrance QTLs that are difficult to map in humans. Leishmaniasis is a well-studied infectious disease with a variety of symptoms and well-defined immunological features. Mouse models of this disease have revealed more than 20 QTLs as being susceptibility genes, studies of which have made important contributions to our understanding of the host response to infection. The functional effects of individual QTLs differ widely, indicating a networked regulation of these effects. Several of these QTLs probably also influence susceptibility to other infections, indicating that their characterization will contribute to our understanding of susceptibility to infectious disease in general. Pracoviště Ústav molekulární genetiky Kontakt Nikol Škňouřilová, nikol.sknourilova@img.cas.cz, Tel.: 241 063 217 Rok sběru 2006
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