Počet záznamů: 1
Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids
- 1.
SYSNO ASEP 0564844 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids Author(s) Szczurowska, Ewa (UOCHB-X)
Szánti-Pintér, Eszter (UOCHB-X) ORCID
Randáková, Alena (FGU-C) RID, ORCID
Jakubík, Jan (FGU-C) RID, ORCID
Kudová, Eva (UOCHB-X) RID, ORCIDArticle number 13075 Source Title International Journal of Molecular Sciences. - : MDPI - ISSN 1661-6596
Roč. 23, č. 21 (2022)Number of pages 18 s. Language eng - English Country CH - Switzerland Keywords neurosteroids ; neuroactive steroids ; cholesterol ; muscarinic receptors ; allosteric modulation OECD category Biochemistry and molecular biology R&D Projects LX22NPO5104 GA MŠMT - Ministry of Education, Youth and Sports (MEYS) Method of publishing Open access Institutional support UOCHB-X - RVO:61388963 ; FGU-C - RVO:67985823 UT WOS 000881456100001 EID SCOPUS 85141881537 DOI https://doi.org/10.3390/ijms232113075 Annotation Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid hormones are molecules of steroid origin that, besides having well-known genomic effects, also modulate membrane proteins including muscarinic acetylcholine receptors. Here, we review current knowledge on the allosteric modulation of muscarinic receptors by these steroids. We give a perspective on the research on the non-genomic effects of steroidal compounds on muscarinic receptors and drug development, with an aim to ultimately exploit such knowledge. Workplace Institute of Organic Chemistry and Biochemistry Contact asep@uochb.cas.cz ; Kateřina Šperková, Tel.: 232 002 584 ; Jana Procházková, Tel.: 220 183 418 Year of Publishing 2023 Electronic address https://doi.org/10.3390/ijms232113075
Počet záznamů: 1