Počet záznamů: 1  

Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids

  1. 1.
    0564844 - ÚOCHB 2023 RIV CH eng J - Článek v odborném periodiku
    Szczurowska, Ewa - Szánti-Pintér, Eszter - Randáková, Alena - Jakubík, Jan - Kudová, Eva
    Allosteric Modulation of Muscarinic Receptors by Cholesterol, Neurosteroids and Neuroactive Steroids.
    International Journal of Molecular Sciences. Roč. 23, č. 21 (2022), č. článku 13075. ISSN 1422-0067. E-ISSN 1422-0067
    Grant CEP: GA MŠMT(CZ) LX22NPO5104
    Institucionální podpora: RVO:61388963 ; RVO:67985823
    Klíčová slova: neurosteroids * neuroactive steroids * cholesterol * muscarinic receptors * allosteric modulation
    Obor OECD: Biochemistry and molecular biology; Physiology (including cytology) (FGU-C)
    Impakt faktor: 5.6, rok: 2022
    Způsob publikování: Open access
    https://doi.org/10.3390/ijms232113075

    Muscarinic acetylcholine receptors are membrane receptors involved in many physiological processes. Malfunction of muscarinic signaling is a cause of various internal diseases, as well as psychiatric and neurologic conditions. Cholesterol, neurosteroids, neuroactive steroids, and steroid hormones are molecules of steroid origin that, besides having well-known genomic effects, also modulate membrane proteins including muscarinic acetylcholine receptors. Here, we review current knowledge on the allosteric modulation of muscarinic receptors by these steroids. We give a perspective on the research on the non-genomic effects of steroidal compounds on muscarinic receptors and drug development, with an aim to ultimately exploit such knowledge.
    Trvalý link: https://hdl.handle.net/11104/0336401

     
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    10.3390ijms232113075.pdf34.3 MBVydavatelský postprintpovolen
     
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