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Increased plasma levels of palmitoleic acid may contribute to beneficial effects of Krill oil on glucose homeostasis in dietary obese mice
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SYSNO ASEP 0531280 Document Type J - Journal Article R&D Document Type Journal Article Subsidiary J Článek ve WOS Title Increased plasma levels of palmitoleic acid may contribute to beneficial effects of Krill oil on glucose homeostasis in dietary obese mice Author(s) Rossmeisl, Martin (FGU-C) RID, ORCID
Pavlišová, Jana (FGU-C)
Bardová, Kristina (FGU-C) RID, ORCID, SAI
Kalendová, Veronika (FGU-C) RID, ORCID
Burešová, Jana (FGU-C) ORCID, RID
Kuda, Ondřej (FGU-C) RID, ORCID, SAI
Kroupová, Petra (FGU-C) ORCID
Staňková, B. (CZ)
Tvrzická, E. (CZ)
Fišerová, E. (CZ)
Horáková, Olga (FGU-C) RID, ORCID
Kopecký, Jan (FGU-C) RID, ORCIDArticle number 158732 Source Title Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. - : Elsevier - ISSN 1388-1981
Roč. 1865, č. 8 (2020)Number of pages 12 s. Language eng - English Country NL - Netherlands Keywords omega-3 PUFA ; krill oil ; insulin resistance ; palmitoleate ; high-fat diet ; C57BL/6 mice Subject RIV FB - Endocrinology, Diabetology, Metabolism, Nutrition OECD category Endocrinology and metabolism (including diabetes, hormones) R&D Projects GA17-11027S GA ČR - Czech Science Foundation (CSF) Method of publishing Limited access Institutional support FGU-C - RVO:67985823 UT WOS 000537835800019 EID SCOPUS 85084365467 DOI https://doi.org/10.1016/j.bbalip.2020.158732 Annotation Omega-3 polyunsatuarted fatty acids (PUFA) are associated with hypolipidemic and anti-inflammatory effects. However, omega-3 PUFA, usually administered as triacylglycerols or ethyl esters, could also compromise glucose metabolism, especially in obese type 2 diabetics. Phospholipids represent an alternative source of omega-3 PUFA, but their impact on glucose homeostasis is poorly explored. Male C57BL/6N mice were fed for 8 weeks a corn oil-based high-fat diet (cHF) alone or cHF-based diets containing eicosapentaenoic acid and docosahexaenoic acid (similar to 3%, wt/wt), admixed either as a concentrate of re-esterified triacylglycerols (omega 3TG) or Krill oil containing mainly phospholipids (omega 3PL). Lean controls were fed a low-fat diet. Insulin sensitivity (hyperinsulinemic-euglycemic clamps), parameters of glucose homeostasis, adipose tissue function, and plasma levels of N-acylethanolamines, monoacylglycerols and fatty acids were determined.Feeding cHF induced obesity and worsened (similar to 4.3-fold) insulin sensitivity as determined by clamp. Insulin sensitivity was almost preserved in omega 3PL but not omega 3TG mice. Compared with cHF mice, endogenous glucose production was reduced to 47%, whereas whole-body and muscle glycogen synthesis increased similar to 3-fold in omega 3PL mice that showed improved adipose tissue function and elevated plasma adiponectin levels. Besides eicosapentaenoic and docosapentaenoic acids, principal component analysis of plasma fatty acids identified palmitoleic acid (C16:1n-7) as the most discriminating analyze whose levels were increased in omega 3PL mice and correlated negatively with the degree of cHF-induced glucose intolerance.While palmitoleic acid from Krill oil may help improve glucose homeostasis, our findings provide a general rationale for using omega-3 PUFA-containing phospholipids as nutritional supplements with potent insulin-sensitizing effects. Workplace Institute of Physiology Contact Lucie Trajhanová, lucie.trajhanova@fgu.cas.cz, Tel.: 241 062 400 Year of Publishing 2021 Electronic address https://doi.org/10.1016/j.bbalip.2020.158732
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