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Increased plasma levels of palmitoleic acid may contribute to beneficial effects of Krill oil on glucose homeostasis in dietary obese mice
- 1.0531280 - FGÚ 2021 RIV NL eng J - Článek v odborném periodiku
Rossmeisl, Martin - Pavlišová, Jana - Bardová, Kristina - Kalendová, Veronika - Burešová, Jana - Kuda, Ondřej - Kroupová, Petra - Staňková, B. - Tvrzická, E. - Fišerová, E. - Horáková, Olga - Kopecký, Jan
Increased plasma levels of palmitoleic acid may contribute to beneficial effects of Krill oil on glucose homeostasis in dietary obese mice.
Biochimica Et Biophysica Acta-Molecular and Cell Biology of Lipids. Roč. 1865, č. 8 (2020), č. článku 158732. ISSN 1388-1981. E-ISSN 1879-2618
Grant CEP: GA ČR(CZ) GA17-11027S
Institucionální podpora: RVO:67985823
Klíčová slova: omega-3 PUFA * krill oil * insulin resistance * palmitoleate * high-fat diet * C57BL/6 mice
Obor OECD: Endocrinology and metabolism (including diabetes, hormones)
Impakt faktor: 4.698, rok: 2020
Způsob publikování: Omezený přístup
Omega-3 polyunsatuarted fatty acids (PUFA) are associated with hypolipidemic and anti-inflammatory effects. However, omega-3 PUFA, usually administered as triacylglycerols or ethyl esters, could also compromise glucose metabolism, especially in obese type 2 diabetics. Phospholipids represent an alternative source of omega-3 PUFA, but their impact on glucose homeostasis is poorly explored. Male C57BL/6N mice were fed for 8 weeks a corn oil-based high-fat diet (cHF) alone or cHF-based diets containing eicosapentaenoic acid and docosahexaenoic acid (similar to 3%, wt/wt), admixed either as a concentrate of re-esterified triacylglycerols (omega 3TG) or Krill oil containing mainly phospholipids (omega 3PL). Lean controls were fed a low-fat diet. Insulin sensitivity (hyperinsulinemic-euglycemic clamps), parameters of glucose homeostasis, adipose tissue function, and plasma levels of N-acylethanolamines, monoacylglycerols and fatty acids were determined.Feeding cHF induced obesity and worsened (similar to 4.3-fold) insulin sensitivity as determined by clamp. Insulin sensitivity was almost preserved in omega 3PL but not omega 3TG mice. Compared with cHF mice, endogenous glucose production was reduced to 47%, whereas whole-body and muscle glycogen synthesis increased similar to 3-fold in omega 3PL mice that showed improved adipose tissue function and elevated plasma adiponectin levels. Besides eicosapentaenoic and docosapentaenoic acids, principal component analysis of plasma fatty acids identified palmitoleic acid (C16:1n-7) as the most discriminating analyze whose levels were increased in omega 3PL mice and correlated negatively with the degree of cHF-induced glucose intolerance.While palmitoleic acid from Krill oil may help improve glucose homeostasis, our findings provide a general rationale for using omega-3 PUFA-containing phospholipids as nutritional supplements with potent insulin-sensitizing effects.
Trvalý link: http://hdl.handle.net/11104/0309968
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