Počet záznamů: 1
In vitro study of 2,3-dehydrosilybin and its galloyl esters as potential inhibitors of angiogenesis
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SYSNO ASEP 0465585 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název In vitro study of 2,3-dehydrosilybin and its galloyl esters as potential inhibitors of angiogenesis Tvůrce(i) Pivodová, V. (CZ)
Zahler, S. (DE)
Karas, D. (CZ)
Valentová, Kateřina (MBU-M) RID, ORCID
Ulrichová, J. (CZ)Zdroj.dok. Pharmazie. - : Avoxa - ISSN 0031-7144
Roč. 71, č. 8 (2016), s. 478-483Poč.str. 6 s. Jazyk dok. eng - angličtina Země vyd. DE - Německo Klíč. slova NF-KAPPA-B ; VASCULAR ENDOTHELIAL-CELLS ; GROWTH-FACTOR Vědní obor RIV EE - Mikrobiologie, virologie CEP GA15-03037S GA ČR - Grantová agentura ČR Institucionální podpora MBU-M - RVO:61388971 UT WOS 000385261200009 EID SCOPUS 84989864018 Anotace 2,3-Dehydrosilybin exhibits substantial anticancer and antiangiogenic effects, which can be potentially improved by semi-synthetic modification such as esterification with gallic acid. The aim of this study was to examine the potential antiangiogenic effect of 2,3-dehydrosilybin and its galloyl esters (3-O-galloyl-2,3-dehydrosilybin; 7-O-galloyl-2,3-dehydrosilybin; 20-O-galloyl-2,3-dehydrosilybin and 23-O-galloyl-2,3-dehydrosilybin) and to determine which molecular mechanism could be responsible for their activity. The effect on cell proliferation, tube formation, signal transduction pathways (PI3K/Akt and ERK) and the cell cycle was studied in human microvascular endothelial cells (HMEC). The results showed that all compounds decreased the growth of HMEC, but the strongest effect was observed for 20-O-galloyl-2,3-dehydrosilybin at 5 mu mol/l. In addition, at 5 and 10 mu mol/l, this was the only compound that significantly inhibited HMEC tube formation. Based on an assessment of Akt and ERK1/2 expression, we suggest that 20-O-galloyl-2,3-dehydrosilybin influences the angiogenic process through the Akt pathway. Pracoviště Mikrobiologický ústav Kontakt Eliška Spurná, eliska.spurna@biomed.cas.cz, Tel.: 241 062 231 Rok sběru 2017
Počet záznamů: 1