Počet záznamů: 1
Primary Investigation of the Preparation of Nanoparticles by Precipitation
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SYSNO ASEP 0434349 Druh ASEP J - Článek v odborném periodiku Zařazení RIV J - Článek v odborném periodiku Poddruh J Článek ve WOS Název Primary Investigation of the Preparation of Nanoparticles by Precipitation Tvůrce(i) Vaculíková, E. (CZ)
Grünwaldová, Veronika (UACH-T)
Král, V. (CZ)
Dohnal, J. (CZ)
Jampílek, J. (CZ)Zdroj.dok. Molecules. - : MDPI - ISSN 1420-3049
Roč. 17, č. 9 (2012), s. 11067-11078Poč.str. 12 s. Jazyk dok. eng - angličtina Země vyd. CH - Švýcarsko Klíč. slova steroids ; nanoparticles ; precipitation ; excipients ; dynamic light scattering Vědní obor RIV CA - Anorganická chemie Institucionální podpora UACH-T - RVO:61388980 UT WOS 000309269700074 EID SCOPUS 84866912657 DOI https://doi.org/10.3390/molecules170911067 Anotace The absorption, distribution, biotransformation and excretion of a drug involve its transport across cell membranes. This process is essential and influenced by the characteristics of the drug, especially its molecular size and shape, solubility at the site of its absorption, relative lipid solubility, etc. One of the progressive ways for increasing bioavaibility is a nanoparticle preparation technique. Cholesterol, cholestenolone and pregnenolone acetate as model active pharmaceutical ingredients and some of the commonly used excipients as nanoparticle stabilizers were used in the investigated precipitation method that was modified and simplified and can be used as an effective and an affordable technique for the preparation of nanoparticles. All 120 prepared samples were analyzed by means of dynamic light scattering (Nanophox). The range of the particle size of the determined 100 nanoparticle samples was from 1 nm to 773 nm, whereas 82 samples contained nanoparticles of less than 200 nm. Relationships between solvents and used excipients and their amount are discussed. Pracoviště Ústav anorganické chemie Kontakt Jana Kroneislová, krone@iic.cas.cz, Tel.: 311 236 931 Rok sběru 2015
Počet záznamů: 1