Počet záznamů: 1  

Primary Investigation of the Preparation of Nanoparticles by Precipitation

  1. 1.
    0434349 - ÚACH 2015 RIV CH eng J - Článek v odborném periodiku
    Vaculíková, E. - Grünwaldová, Veronika - Král, V. - Dohnal, J. - Jampílek, J.
    Primary Investigation of the Preparation of Nanoparticles by Precipitation.
    Molecules. Roč. 17, č. 9 (2012), s. 11067-11078. E-ISSN 1420-3049
    Institucionální podpora: RVO:61388980
    Klíčová slova: steroids * nanoparticles * precipitation * excipients * dynamic light scattering
    Kód oboru RIV: CA - Anorganická chemie
    Impakt faktor: 2.428, rok: 2012

    The absorption, distribution, biotransformation and excretion of a drug involve its transport across cell membranes. This process is essential and influenced by the characteristics of the drug, especially its molecular size and shape, solubility at the site of its absorption, relative lipid solubility, etc. One of the progressive ways for increasing bioavaibility is a nanoparticle preparation technique. Cholesterol, cholestenolone and pregnenolone acetate as model active pharmaceutical ingredients and some of the commonly used excipients as nanoparticle stabilizers were used in the investigated precipitation method that was modified and simplified and can be used as an effective and an affordable technique for the preparation of nanoparticles. All 120 prepared samples were analyzed by means of dynamic light scattering (Nanophox). The range of the particle size of the determined 100 nanoparticle samples was from 1 nm to 773 nm, whereas 82 samples contained nanoparticles of less than 200 nm. Relationships between solvents and used excipients and their amount are discussed.
    Trvalý link: http://hdl.handle.net/11104/0238428

     
     
Počet záznamů: 1  

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