0193792 - UOCHB-X 20000224 RIV CZ eng J - Journal Article
Hlaváček, Jan - Marcová, Renata - Buděšínský, Miloš - Slaninová, Jiřina
1-deamino-1(15)-carba and -dicarba analogues of endothelin-1.
Collection of Czechoslovak Chemical Communications. Roč. 65, č. 3 (2000), s. 407-424. ISSN 0010-0765
R&D Projects: GA ČR GA203/97/0155; GA ČR GA203/98/1330
Institutional research plan: CEZ:AV0Z4055905
Subject RIV: CC - Organic Chemistry
Impact factor: 0.960, year: 2000

The carba and di-carba analogues of endothelin-1 were synthesized either by a fragment condensation of protected cyclic pentadecapeptides with carboxy-terminal hexapeptides or by step-wise coupling on polymer support from carboxy-terminus. Analogues were devoid of uterotonic activity in comparison with the parent endothelin-1.
Permanent Link: http://hdl.handle.net/11104/0089484