0173812 - UEM-P 20033138 RIV US eng J - Článek v odborném periodiku
Botros, S. - William, S. - Hammam, O. - Zídek, Zdeněk - Holý, Antonín
Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice.
Antimicrobial Agents and Chemotherapy. Roč. 47, č. 12 (2003), s. 3853-3858. ISSN 0066-4804. E-ISSN 1098-6596
Grant CEP: GA ČR GA305/00/0048; GA ČR GA305/03/1470
Výzkumný záměr: CEZ:AV0Z5008914; CEZ:AV0Z5039906
Klíčová slova: schistosoma mansoni
Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
Impakt faktor: 4.246, rok: 2003

Administration of one of the acyclic nucleoside phosphonates, HPMPA, to mice infected with Schistosoma mansoni resulted in suppression of total numbers of female and coupled worms, complete disappearance of immature and mature ggs, with 99-100% of the eggs being dead. Greatly reduced or no hepatic egg-induced granulomas were present in treated mice.
Trvalý link: http://hdl.handle.net/11104/0070838