Počet záznamů: 1  

Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice

  1. 1. 0173812 - UEM-P 20033138 RIV US eng J - Článek v odborném periodiku
    Botros, S. - William, S. - Hammam, O. - Zídek, Zdeněk - Holý, Antonín
    Activity of 9-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]adenine against Schistosomiasis mansoni in mice.
    Antimicrobial Agents and Chemotherapy. Roč. 47, č. 12 (2003), s. 3853-3858 ISSN 0066-4804
    Grant CEP: GA ČR GA305/00/0048; GA ČR GA305/03/1470
    Výzkumný záměr: CEZ:AV0Z5008914; CEZ:AV0Z5039906
    Klíčová slova: schistosoma mansoni
    Kód oboru RIV: FH - Neurologie, neurochirurgie, neurovědy
    Impakt faktor: 4.246, rok: 2003

    Administration of one of the acyclic nucleoside phosphonates, HPMPA, to mice infected with Schistosoma mansoni resulted in suppression of total numbers of female and coupled worms, complete disappearance of immature and mature ggs, with 99-100% of the eggs being dead. Greatly reduced or no hepatic egg-induced granulomas were present in treated mice.
    Trvalý link: http://hdl.handle.net/11104/0070838